PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

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ID: 113780
1999
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Abstract
Agonist-induced activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) is known to cause adipocyte differentiation and insulin sensitivity. The biological role of PPAR gamma was investigated by gene targeting. Homozygous PPAR gamma-deficient embryos died at 10.5-11.5 dpc due to ā€¦
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Authors Kubota N;Terauchi Y;Miki H;Tamemoto H;Yamauchi T;Komeda K;Satoh S;Nakano R;Ishii C;Sugiyama T;Eto K;Tsubamoto Y;Okuno A;Murakami K;Sekihara H;Hasegawa G;Naito M;Toyoshima Y;Tanaka S;Shiota K;Kitamura T;Fujita T;Ezaki O;Aizawa S;Kadowaki T;;
Journal molecular cell
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10549291
Keywords
diet National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Receptors Blood Glucose / metabolism Knockout cytoplasmic and nuclear / genetics* cytoplasmic and nuclear / metabolism transcription factors / genetics* transcription factors / metabolism adipocytes / metabolism* placenta / pathology hypoglycemic agents / pharmacology pioglitazone myocardium / pathology pmid:10549291 doi:10.1016/s1097-2765(00)80210-5 n kubota y terauchi t kadowaki body weight / genetics cell differentiation / genetics cell size / genetics* eating energy metabolism fats / pharmacology* fetal viability / genetics insulin resistance / genetics* leptin / metabolism cytoplasmic and nuclear / agonists thiazoles / pharmacology thiazolidinediones* transcription factors / agonists

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