Synthesis and Spectroscopic Analysis of Novel 1<em>H</em>-Benzo[<em>d</em>]imidazoles Phenyl Sulfonylpiperazines

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ID: 96133
2012
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Abstract
A group of benzimidazole analogs of sildenafil, 3-benzimidazolyl-4-methoxy-phenylsulfonylpiperazines <strong>2</strong><strong>ā€“4 </strong>and 3-benzimidazolyl-4-methoxy-<em>N,N</em>-dimethyl- benzenesulfonamide (<strong>5</strong>),<strong> </strong>were efficiently synthesized. Compounds <strong>2</strong><strong>ā€“5</strong> were characterized by NMR and MS and contrary to the reported mass spectra of sildenafil, the spectra of the piperazine-containing compounds <strong>2</strong><strong>ā€“4</strong> showed a novel fragmentation pattern leading to an <em>m/z</em> = 316. A mechanism for the formation of this fragment was proposed.
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qandil2012synthesispharmaceuticals Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Qandil, Amjad M.;
Journal pharmaceuticals
Year 2012
DOI DOI not found
URL
http://www.mdpi.com/1424-8247/5/5/460
Keywords
chemistry Pharmacy and materia medica Biology (General) Engineering (General). Civil engineering (General) Science (General) Science

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