MDR/XDR-TB management of patients and contacts: challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network.

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2020
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Abstract
The continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.
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Authors Battista Migliori, Giovanni;Tiberi, Simon;Zumla, Alimuddin;Petersen, Eskild;Muhwa Chakaya, Jeremiah;Wejse, Christian;Muñoz Torrico, Marcela;Duarte, Raquel;Alffenaar, Jan Willem;Schaaf, H Simon;Marais, Ben J;Cirillo, Daniela Maria;Alagna, Riccardo;Rendon, Adrian;Pontali, Emanuele;Piubello, Alberto;Figueroa, José;Ferlazzo, Gabriella;García-Basteiro, Alberto;Centis, Rosella;Visca, Dina;D'Ambrosio, Lia;Sotgiu, Giovanni;, ;
Journal International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Year 2020
DOI S1201-9712(20)30045-X
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