Total synthesis of aristolactam alkaloids synergistic C-H bond activation and dehydro-Diels-Alder reactions.

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2017
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Abstract
A concise total synthesis of aristolactam alkaloids by a synergistic combination of C-H bond activation and dehydro-Diels-Alder reactions is described. To achieve the synthesis two new synthetic methodologies, namely the oxidative cyclization of benzamides with vinyl sulfone leading to 3-methyleneisoindolin-1-ones a ruthenium-catalyzed C-H bond activation, and a dehydro-Diels-Alder reaction followed by the fluoride ion mediated desulfonylation of 3-methyleneisoindolin-1-ones with benzynes, were developed. The method presented allows the opportunity for the construction of all the rings of aristolactams from easily available starting materials.
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reddy2017totalchemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Reddy, Mallu Chenna;Jeganmohan, Masilamani;
Journal Chemical science
Year 2017
DOI 10.1039/c7sc00161d
URL
Keywords
nephrotoxicity metabolomics lc-ms asarum aristolactam

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