A novel TRIM family member, Trim69, regulates zebrafish development through p53-mediated apoptosis.

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ID: 86787
2016
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Abstract
Trim69 contains the hallmark domains of a tripartite motif (TRIM) protein, including a Ring-finger domain, B-box domain, and coiled-coil domain. Trim69 is structurally and evolutionarily conserved in zebrafish, mouse, rat, human, and chimpanzee. The role of this protein is unclear, however, so we investigated its function in zebrafish development. Trim69 is extensively expressed in zebrafish adults and developing embryos-particularly in the testis, brain, ovary, and heart-and its expression decreases in a time- and stage-dependent manner. Loss of trim69 in zebrafish induces apoptosis and activates apoptosis-related processes; indeed, the tp53 pathway was up-regulated in response to the knockdown. Expression of human trim69 rescued the apoptotic phenotype, while overexpression of trim69 does not increase cellular apoptosis. Taken together, our results suggest that trim69 participates in tp53-mediated apoptosis during zebrafish development. Mol. Reprod. Dev. 83: 442-454, 2016. Ā© 2016 Wiley Periodicals, Inc.
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han2016amolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Han, Ruiqin;Zhao, Qing;Zong, Shudong;Miao, Shiying;Song, Wei;Wang, Linfang;
Journal molecular reproduction and development
Year 2016
DOI 10.1002/mrd.22643
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Keywords
public health qualitative research immunisation delivery of health services health reforms organisational change

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