Challenges in Alzheimer Disease Drug Discovery and Development: The Role of Modeling, Simulation and Open Data.

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ID: 84448
2020
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Abstract
Alzheimer disease (AD) is the leading cause of dementia worldwide. With 35 million people over 60 years of age with dementia, there is an urgent need to develop new treatments for AD. To streamline this process, it is imperative to apply insights and learnings from past failures to future drug development programs. In the present work, we focus on how modeling and simulation (M&S) tools can leverage open data to address drug development challenges in AD.
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conrado2020challengesclinical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Conrado, Daniela J;Duvvuri, Sridhar;Geerts, Hugo;Burton, Jackson;Biesdorf, Carla;Ahamadi, Malidi;Macha, Sreeraj;Hather, Gregory;Morales, Juan Francisco;Podichetty, Jagdeep;Nicholas, Timothy;Stephenson, Diane;Trame, Mirjam;Romero, Klaus;Corrigan, Brian;, ;
Journal clinical pharmacology and therapeutics
Year 2020
DOI 10.1002/cpt.1782
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Keywords
Simulation alzheimer disease modeling open data open science challenges drug discovery drug development novel technologies

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