Controlled arterial hypertension and adverse event free survival rate in heart recipients

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2018
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Abstract
Aim. To evaluate the prevalence of arterial hypertension (AH) in heart transplant recipients, and its influence on the risk of adverse events, as the efficacy and safety of antihypertension medications (AHM).Material and methods. To the study, were consequently included all heart transplant recipients operated in the Shumakov Centre during the years 2013 to 2016 and survived 90 days after orthotopic heart transplantation.Results. Totally, 353 recipients included, with AH or AHM intake in anamnesis in 62 (17,6%). Within 90 days post-surgery, AH that demanded  for medication therapy was found in 151 (42,8%) patients. In posttransplant AH patients there were the following specific parameters in preoperational period: higher body mass index — 25,7±4,1 vs 24,9±4,4 (р=0,026), blood creatinine concentration — 100,6±62,6 vs 68,8±4,8 (р<0,001), donor heart posterior wall thickness — 11,9±0,8 vs 11,3±0,7 (р=0,034), creatinine concentration in 3 month after operation  — 131,7±101,6 vs 94,1±46,5 (p<0,001). There was relation revealed, of AH development risk with anamnesis of AH and renal failure, as a necessity for renal replacement therapy within 30 days post surgery and episodes of acute antibody-mediated reaction on transplant. In the recipients taking angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ACEi/ARB) before operation, the survival rate free from adverse events was better than in those taking calcium channel blockers (CCB) (plog-rank=0,042).Conclusion. The results of the study point on high prevalence of AH in heart recipients. Presence of AH in anamnesis, renal failure, episodes of humoral, but not cellular, reaction to the transplant, and donor heart hypertrophy do significantly increase the probability of AH development after transplantation. Comparison revealed significant benefit of ACEi/ ARB versus CCB as antihypertension medications in either monotherapy or in combination with diuretics.
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shevchenko2018controlled Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shevchenko, A. О.;Nikitina, E. A.;Koloskova, N. N.;Shevchenko, О. P.;Gotje, S. V.;
Journal Кардиоваскулярная терапия и профилактика
Year 2018
DOI DOI not found
URL
https://cardiovascular.elpub.ru/jour/article/view/774
Keywords
Veterinary medicine Medicine (General) Medicine Technology (General) Engineering (General). Civil engineering (General) Information technology Science Agriculture (General) Dentistry Diseases of the circulatory (Cardiovascular) system neurosciences. biological psychiatry. neuropsychiatry sports telecommunication computer engineering. computer hardware

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