Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents.
Clicks: 240
ID: 78131
2019
In an effort to improve the antimicrobial activity of norfloxacin, a series of hybrid norfloxacin-thiazolidinedione molecules were synthesized and screened for their direct antimicrobial activity and their anti-biofilm properties. The new hybrids were intended to have a new binding mode to DNA gyrase, that will allow for a more potent antibacterial effect, and for activity against current quinolone-resistant bacterial strains. Moreover, the thiazolidinedione moiety aimed to include additional anti-pathogenicity by preventing biofilm formation. The resulting compounds showed promising direct activity against Gram-negative strains, and anti-biofilm activity against Gram-positive strains. Docking studies and ADMET were also used in order to explain the biological properties and revealed some potential advantages over the parent molecule norfloxacin.
| Reference Key |
marc2019designmolecules
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Marc, Gabriel;Araniciu, Cătălin;Oniga, Smaranda Dafina;Vlase, Laurian;Pîrnău, Adrian;Nadăș, George Cosmin;Novac, Cristiana Ștefania;Matei, Ioana Adriana;Chifiriuc, Mariana Carmen;Măruțescu, Luminița;Oniga, Ovidiu; |
| Journal | Molecules (Basel, Switzerland) |
| Year | 2019 |
| DOI | E3959 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.