Ribosomal incorporation of aromatic oligoamides as peptide side-chain appendages.
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2020
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Abstract
Derivatives of 4-aminomethyl-L-phenylalanine having aromatic oligoamide foldamers as side chain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent ribosomal incorporation both at the C-terminus of, and within, peptide sequences, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome machinery to side-chains significantly larger and more structurally defined than was previously known.| Reference Key |
tsiamantas2020ribosomalangewandte
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| Authors | Tsiamantas, Christos;Kwon, Sunbum;Rogers, Joseph Matthew;Douat, Céline;Huc, Ivan;Suga, Hiroaki; |
| Journal | angewandte chemie (international ed in english) |
| Year | 2020 |
| DOI | 10.1002/anie.201914654 |
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