Photoredox-Mediated Remote C(sp)-H Heteroarylation of -Alkyl Sulfonamides.

Clicks: 282
ID: 70145
2019
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
A Minisci-type Ī“-selective C(sp)-H heteroarylation of sulfonyl-protected primary aliphatic amines with -heteroarenes under photoredox-catalyzed conditions was developed. The reaction typically uses a slight excess of amine reactant. The use of benziodoxole acetate (BI-OAc) oxidant and hexafluoroisopropanol solvent is critical to achieve high yield. Besides methylene C-H bonds, heteroarylation reactions of Ī“ methyl C-H bonds also worked under more forced conditions. The reactions show a broad scope for both amine and -heteroarene substrates, offering a straightforward method for synthesis of complex Ī“-heteroarylalkylmines from simple precursors.
Reference Key
deng2019photoredoxmediatedthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Deng, Zhiqiang;Li, Guo-Xing;He, Gang;Chen, Gong;
Journal The Journal of organic chemistry
Year 2019
DOI 10.1021/acs.joc.9b02502
URL
Keywords
multidrug-resistant brazil one health esbl bacterial pathogens pets

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.