Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole -glycosides.
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ID: 64094
2019
New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds. Click strategy was also used for the synthesis of new 1,3,4-thiadiazole and 1,2,3-triazole hybrid glycosides by reaction of the acetylenic derivatives with different glycosyl azids followed by deacetylation process. The cytotoxic activities of the prepared compounds were studied against HCT-116 (human colorectal carcinoma) and MCF-7 (human breast adenocarcinoma) cell lines using the MTT assay. The results showed that the key thiadiazolethione compounds and , the triazole glycosides linked to -methoxyarylidine derivatives and in addition to the free hydroxyl glycoside were found potent in activity comparable to the reference drug doxorubicin against MCF-7 human cancer cells. The acetylenic derivative and glycoside were also found highly active against HCT-116 cell lines.
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| Authors | Alminderej, Fahad M;Elganzory, Hussein H;El-Bayaa, Mohamed N;Awad, Hanem M;El-Sayed, Wael A; |
| Journal | Molecules (Basel, Switzerland) |
| Year | 2019 |
| DOI | E3738 |
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