Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine.
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2019
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Abstract
New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT receptor inhibiting tumor necrosis factor alpha signaling. Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.| Reference Key |
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| Authors | Tariq, Zeshan;Board, Nathan;Eftimiades, Alex;Ibrahim, Ronnie; |
| Journal | sage open medical case reports |
| Year | 2019 |
| DOI | 10.1177/2050313X19847804 |
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