AS1411 aptamer-decorated cisplatin-loaded poly(lactic-co-glycolic acid) nanoparticles for targeted therapy of miR-21-inhibited ovarian cancer cells.

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2018
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Abstract
The overexpression of miRNA-21 correlates with the cisplatin (CIS) resistance in the ovarian cancers.AS1411 antinucleolin aptamer-decorated PEGylated poly(lactic-co-glycolic acid) nanoparticles containing CIS (Ap-CIS-NPs) and anti-miR-21 (Ap-anti-miR-21-NPs) were prepared, physicochemically investigated and their cancer-targeting ability was confirmed. CIS-resistant A2780 cells (A2780 R) were infected with anti-miR-21 using Ap-anti-miR-21-NPs to decrease the drug resistance and sensitize the cells to CIS. Afterward, miR-21-inhibited cells were exposed to the Ap-CIS-NPs.Ap-anti-miR-21-NPs could infect the A2780 R cells mainly through nucleolin-mediated endocytosis and inhibit the endogenous miR-21. Targeted delivery of CIS using Ap-CIS-NPs into the miR-21-inhibited cells caused an enhanced mortality.The targeted delivery of chemotherapeutics to the oncomiR-inhibited cells may find a robust application in cancer chemo/gene therapy.
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vandghanooni2018as1411nanomedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Vandghanooni, Somayeh;Eskandani, Morteza;Barar, Jaleh;Omidi, Yadollah;
Journal nanomedicine (london, england)
Year 2018
DOI 10.2217/nnm-2018-0205
URL
Keywords
Chemotherapy gene therapy ovarian cancer targeted delivery mir-21 cisplatin as1411 aptamer plga nanoparticles antisense chemoresistant

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