Site-Selective Carbonylative Synthesis of Structurally Diverse Lactams from Heterocyclic Amines with TFBen as the CO Source.
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2019
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Abstract
A palladium-catalyzed site-selective C-H carbonylation of heterocyclic amines for the synthesis of lactam motifs has been developed. The reaction of 3-thiophene methylamines, 2-thiophene methylamines, and tryptamines with benzene-1,3,5-triyl triformate (TFBen) as the CO source provides a series of structurally diverse lactams in moderate to high yields with excellent regioselectivities.
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| Authors | Ying, Jun;Gao, Qian;Wu, Xiao-Feng; |
| Journal | The Journal of organic chemistry |
| Year | 2019 |
| DOI | 10.1021/acs.joc.9b02114 |
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