Selective C(sp)-H Halogenation of "Click" 4-Aryl-1,2,3-triazoles.
Clicks: 276
ID: 57904
2017
Selective bromination reactions of "click compounds" are described. Electron-neutral and electron-deficient arenes selectively undergo unprecedented Pd-catalyzed C-H ortho-halogenations assisted by simple triazoles as modular directing groups, whereas electron-rich arenes are regioselectively halogenated following an electrophilic aromatic substitution reaction pathway. These C-H halogenation procedures exhibit a wide group tolerance, complement existing bromination procedures, and represent versatile synthetic tools of utmost importance for the late-stage diversification of "click compounds". The characterization of a triazole-containing palladacycle and density functional theory studies supported the mechanism proposal.
| Reference Key |
goitia2017selectiveorganic
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Goitia, Asier;Gómez-Bengoa, Enrique;Correa, Arkaitz; |
| Journal | Organic letters |
| Year | 2017 |
| DOI | 10.1021/acs.orglett.7b00275 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.