LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

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ID: 55244
2019
The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.
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kaur2019lipidiinature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kaur, Prabhjot;Rausch, Marvin;Malakar, Basanti;Watson, Uchenna;Damle, Nikhil P.;Chawla, Yogesh;Srinivasan, Sandhya;Sharma, Kanika;Schneider, Tanja;Jhingan, Gagan Deep;Saini, Deepak;Mohanty, Debasisa;Grein, Fabian;Nandicoori, Vinay Kumar;
Journal Nature communications
Year 2019
DOI DOI not found
URL
http://link.springer.com/article/10.1038/s41467-019-09223-9
Keywords
Organic Chemistry Microbiology Science

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