Semi-synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity.

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ID: 50524
2019
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Abstract
In this study, we report our contribution to the application of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of β-keto-1,2,3-triazole derivatives from ethinylestradiol and their application in the inhibition of two human cancer cells lines: human breast adenocarcinoma (MCF-7) and human hepatocellular carcinoma (HepG2). The β-keto-1,2,3-triazole derivates exhibited moderate cytotoxic activity for the HepG2 cells with IC values of 29.7 μM (), 16.4 μM (), 17.8 μM (), 20.4 μM (), 28.1 μM () and 28.2 μM (). The semi-synthetic β-keto-1,2,3-triazoles derivatives were all characterized by FT-IR, NMR, HRMS and [α].
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queiroz2019semisynthesisheliyon Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Queiroz, Thayane M;Orozco, Erika V M;Silva, Valdenizia R;Santos, Luciano S;Soares, Milena B P;Bezerra, Daniel P;Porto, André L M;
Journal Heliyon
Year 2019
DOI 10.1016/j.heliyon.2019.e02408
URL
Keywords
Organic Chemistry hepatocellular carcinoma click reaction toxicology breast adenocarcinoma ethinylestradiol pharmaceutical chemistry β-keto-1,2,3-triazoles

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