Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

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2008
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Abstract
The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.
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Authors Barton, Anne;Thomson, Wendy;Ke, Xiayi;Eyre, Steve;Hinks, Anne;Bowes, John;Plant, Darren;Gibbons, Laura J;, ;, ;, ;Wilson, Anthony G;Bax, Deborah E;Morgan, Ann W;Emery, Paul;Steer, Sophia;Hocking, Lynne;Reid, David M;Wordsworth, Paul;Harrison, Pille;Worthington, Jane;
Journal nature genetics
Year 2008
DOI 10.1038/ng.218
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