Nickel-Catalyzed Double Dehydrogenative Coupling of Secondary Alcohols and β-Amino Alcohols to Access Substituted Pyrroles.

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2019
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Abstract
Herein, we demonstrated the first nickel-catalyzed double dehydrogenative condensation of secondary alcohols and β-amino alcohols in one-pot operation to the pyrrole derivatives. A series of 2,5 and 2,3,5-substituted pyrroles were obtained in up to 83% yield, releasing water and hydrogen gas as by-products. Initial mechanistic studies including defined Ni-catalysts, deuterium labeling experiments, quantitative determination of hydrogen gas evaluation and detection of water generation in the reaction mixture were performed.
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Authors Alanthadka, Anitha;Bera, Sourajit;Vellakkaran, Mari;Banerjee, Debasis;
Journal The Journal of organic chemistry
Year 2019
DOI 10.1021/acs.joc.9b01819
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Keywords
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