Comparison of two beam angular optimization algorithms guided by automated multicriterial IMRT.

To compare two beam angle optimization (BAO) algorithms for coplanar and non-coplanar geometries in a multicriterial optimization framework.40 nasopharynx patients were selected for this retrospective planning study. IMRT optimized plans were produced by Erasmus-iCycle multicriterial optimization platform. Two different algorithms, based on a discrete and on a continuous exploration of the space search, algorithm i and B respectively, were used to address BAO. Plan quality evaluation and comparison were performed with SPIDERplan. Statistically significant differences between the plans were also assessed.For plans using only coplanar incidences, the optimized beam distribution with algorithm i is more asymmetric than with algorithm B. For non-coplanar beam optimization, larger deviations from coplanarity were obtained with algorithm i than with algorithm B. Globally, both algorithms presented near equivalent plan quality scores, with algorithm B presenting a marginally better performance than algorithm i.Almost all plans presented high quality, profiting from multicriterial and beam angular optimization. Although there were not significant differences when average results over the entire sample were considered, a case-by-case analysis revealed important differences for some patients.