Detection of DNA hybridization using electrochemical impedance spectroscopy and surface enhanced Raman scattering

Clicks: 389
ID: 43059
2012
The formation of double-stranded DNA (dsDNA) at gold electrodes decorated with a monolayer of gold nanoparticles bound through a self-assembled dithiol monolayer is detected via specific intercalation of proflavine. Hybridization as well as sequential built-up of the electrode architecture is monitored using Faradaic electrochemical impedance spectroscopy (EIS) as well as surface enhanced Raman scattering (SERS). The adsorption of secondary gold nanoparticles allow for amplified detection of the dsDNA integrated intercalator in a vertical gap mode configuration. The experimental design thus allows probing presence of the intercalator inside the dsDNA. Keywords: SERS, EIS, Intercalator, dsDNA, Hybridization, Vertical gap mode
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grutzke2012detectionelectrochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Grützke, Stefanie;Abdali, Salim;Schuhmann, Wolfgang;Gebala, Magdalena;
Journal electrochemistry communications
Year 2012
DOI DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S1388248112001257
Keywords
chemistry microscopy Biology (General) Engineering (General). Civil engineering (General) Industrial electrochemistry Technology Electrical engineering. Electronics. Nuclear engineering Descriptive and experimental mechanics

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