In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis.

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2018
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Abstract
Antiprotozoal activity of 36 medicinal plants was evaluated.In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined.Maytenus parviflora showed the highest activity against T. b. brucei (IC of 0.6 μg/ml) and T. b. rhodesiense (IC of 0.5 μg/ml) with low cytotoxicity (CC of 30 μg/ml). Saussurea costus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC of 3.6 and 2.5 μg/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC of 3.2 and 2.0 μg/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity.
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Authors Okba, Mona M;Sabry, Omar M;Matheeussen, An;Abdel-Sattar, Essam;
Journal Future medicinal chemistry
Year 2018
DOI 10.4155/fmc-2018-0180
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