Fluorene/fluorenone carboxamide derivatives as selective light-up fluorophores for c-myc G-quadruplex.
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ID: 277455
2021
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Abstract
The development of fluorescent dyes capable of selective recognition of G-quadruplexes is essential for studying its localization and biological functions. However, considering the G-quadruplex topologies may vary significantly, the synthesis of compounds showing both selectivity and strong fluorescence properties still remains a great challenge. Recently we have developed fluorene/fluorenone derivatives with structure-specific binding towards dsRNA, indicating its potential for structure-selective ligands. Herein, we report the synthesis of novel fluorene/fluorenone derivatives and their selectivity towards various DNA structures, particularly G-quadruplexes, two of which showed strong affinity to the proto-oncogene c-myc promoter G-quadruplex.| Reference Key |
duyar2021fluorenefluorenonebioorganic
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| Authors | Duyar, Halil;Portakal, Hüseyin S;Yalçın, Ergin;Kanat, Beyza;Doluca, Osman;Seferoğlu, Zeynel; |
| Journal | Bioorganic & medicinal chemistry letters |
| Year | 2021 |
| DOI | 10.1016/j.bmcl.2021.127824 |
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