Biological Activity of Biosynthesized Silver Nanoaggregates Prepared from the Aqueous Extract of against spp.

Abstract

is commonly used in folk medicine for the treatment of nervous and gastrointestinal disturbances and other medical issues because of its potent antioxidant capacity. The current study evaluated the anti-candida effects of silver nanoparticles (AgNPs) synthesized from an aqueous extract of against different spp. The aqueous extract was prepared from the fresh leaves of . The silver nanoparticles (AgNPs) were prepared and validated by UV spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscope (TEM), and zeta size analysis. , , , , , , and were used in the antifungal assay. Microscopical imaging were used to investigate the different morphological changes induced by treatment. FTIR spectrum confirmed the existence of various functional groups of biomolecules capping the nanoparticles. The average particle size of synthesized AgNPs was 100.6 nm by zeta-sizer and 0.012 to 0.059 mm by TEM. In the antifungal assay, AgNPs aggregates induced significant inhibition of the growth of all species ( < 0.05) compared to the control and the biofilm maturation in and . These considerable antifungal activities might lead to the development of appropriate alternative remedy for the treatment of fungal infections.