Evalution of the castrated male Sprague-Dawley rat as a model of the metabolic syndrome and type 2 diabetes

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ID: 274755
2006
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Abstract
Compared to humans rats respond differently to testosterone deficiency. Only few of the features typical for the human metabolic syndrome were observed in castrated male Sprague-Dawley rats. Therefore, we conclude that with the present experimental setup the castrated rat is not an optimal model for ā€¦
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Authors Christoffersen B;Raun K;Svendsen O;Fledelius C;Golozoubova V;;
Journal international journal of obesity (2005)
Year 2006
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16505834
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine male Disease Models animal* Rats Sprague-Dawley Random Allocation body composition / physiology Blood Glucose / metabolism adipose tissue / metabolism diabetes mellitus area under curve testosterone / blood* type 2 / blood testosterone / deficiency type 2 / epidemiology type 2 / etiology* pmid:16505834 doi:10.1038/sj.ijo.0803261 b christoffersen k raun v golozoubova metabolic syndrome / blood metabolic syndrome / epidemiology metabolic syndrome / etiology* orchiectomy*

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