A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS

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ID: 274672
2020
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Abstract
Vaccines are urgently needed to control the ongoing pandemic COVID-19 and previously emerging MERS/SARS caused by coronavirus (CoV) infections. The CoV spike receptor-binding domain (RBD) is an attractive vaccine target but is undermined by limited immunogenicity. We describe a dimeric form of MERS- ā€¦
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Authors Dai L;Zheng T;Xu K;Han Y;Xu L;Huang E;An Y;Cheng Y;Li S;Liu M;Yang M;Li Y;Cheng H;Yuan Y;Zhang W;Ke C;Wong G;Qi J;Qin C;Yan J;Gao GF;;
Journal Cell
Year 2020
DOI DOI not found
URL
https://www.pubmed.gov/32645327/
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE Mice covid-19 sars-cov-2 animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Antibodies cell line Inbred BALB C Receptors pneumonia viral / immunology chlorocebus aethiops vero cells transfection viral / virology protein binding coronavirus infections / prevention & control* pandemics / prevention & control* viral / prevention & control* specific pathogen-free organisms hek293 cells betacoronavirus / immunology* coronavirus infections / virology spodoptera covid-19 vaccines pmid:32645327 pmc7321023 doi:10.1016/j.cell.2020.06.035 lianpan dai tianyi zheng george f gao angiotensin-converting enzyme 2 neutralizing / immunology betacoronavirus / chemistry middle east respiratory syndrome coronavirus / chemistry middle east respiratory syndrome coronavirus / immunology* peptidyl-dipeptidase a / genetics peptidyl-dipeptidase a / metabolism protein interaction domains and motifs / immunology virus / metabolism sars virus / chemistry sars virus / immunology* sf9 cells universal design* vaccination / methods viral vaccines

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