FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells

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ID: 274572
2010
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Abstract
TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has been linked to invasive properties of prostate cancers, the precise mechanisms and pathways of ERG-mediated oncogenesis remain poorly understood ā€¦
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Authors Gupta S;Iljin K;Sara H;Mpindi JP;Mirtti T;Vainio P;Rantala J;Alanen K;Nees M;Kallioniemi O;;
Journal Cancer research
Year 2010
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20713528
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male cell line Receptors signal transduction / genetics transfection neoplastic up-regulation gene silencing epithelial cells / pathology wnt proteins / metabolism* prostatic neoplasms / metabolism prostatic neoplasms / pathology gene knockdown techniques prostatic neoplasms / genetics frizzled receptors / metabolism trans-activators / biosynthesis g-protein-coupled / genetics* pmid:20713528 doi:10.1158/0008-5472.can-10-0244 santosh gupta kristiina iljin olli kallioniemi cadherins / biosynthesis cadherins / genetics cell adhesion / genetics frizzled receptors / genetics* integrin beta1 / biosynthesis integrin beta1 / genetics mesoderm / pathology g-protein-coupled / metabolism trans-activators / genetics* transcriptional regulator erg

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