Identification and characterization of a novel botulinum neurotoxin

Clicks: 146
ID: 274522
2017
Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated …
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Authors Zhang S;Masuyer G;Zhang J;Shen Y;Lundin D;Henriksson L;Miyashita SI;Martínez-Carranza M;Dong M;Stenmark P;;
Journal Nature communications
Year 2017
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/28770820
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Molecular animals humans pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't N.I.H. Extramural amino acid motifs amino acid sequence sequence alignment botulinum toxins / metabolism* pmid:28770820 pmc5543303 doi:10.1038/ncomms14130 sicai zhang geoffrey masuyer pål stenmark botulinum toxins / chemistry botulinum toxins / genetics botulinum toxins / toxicity botulism / genetics botulism / metabolism botulism / microbiology* clostridium botulinum / enzymology* clostridium botulinum / genetics neurotoxins / chemistry neurotoxins / genetics neurotoxins / metabolism* neurotoxins / toxicity r-snare proteins / chemistry r-snare proteins / genetics r-snare proteins / metabolism vesicle-associated membrane protein 2 / chemistry vesicle-associated membrane protein 2 / genetics vesicle-associated membrane protein 2 / metabolism

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