Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase

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ID: 274320
2014
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Abstract
A polyspecific amber suppressor aminoacyl-tRNA synthetase/tRNA pair was evolved that genetically encodes a series of histidine analogues in both Escherichia coli and mammalian cells. In combination with tRNACUA(Pyl), a pyrrolysyl-tRNA synthetase mutant was able to site-specifically incorporate 3-met ā€¦
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Authors Xiao H;Peters FB;Yang PY;Reed S;Chittuluru JR;Schultz PG;;
Journal ACS chemical biology
Year 2014
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24506189
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Molecular pubmed abstract nih national institutes of health national library of medicine models research support N.I.H. Extramural mutation letter luminescent proteins / genetics alanine / analogs & derivatives protein engineering / methods* escherichia coli / genetics* mutant proteins / genetics pmid:24506189 pmc4033645 doi:10.1021/cb500032c han xiao francis b peters peter g schultz alanine / genetics amino acyl-trna synthetases / genetics* histidine / analogs & derivatives* histidine / genetics*

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