Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events? A systematic review

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ID: 274199
2016
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Abstract
This systematic review found little published evidence to support an optimal dosage regimen or TDM targets for amikacin therapy. The use of alternative approaches, such as consensus opinion and a review of current practice, will be required to develop guidelines to maximize therapeutic outcomes and ā€¦
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Authors Jenkins A;Thomson AH;Brown NM;Semple Y;Sluman C;MacGowan A;Lovering AM;Wiffen PJ; ;;
Journal The Journal of antimicrobial chemotherapy
Year 2016
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/27494904
Keywords
systematic review National Center for Biotechnology Information NCBI NLM MEDLINE review humans pubmed abstract nih national institutes of health national library of medicine treatment outcome adult anti-bacterial agents / therapeutic use anti-bacterial agents / administration & dosage* dose-response relationship drug drug-related side effects and adverse reactions amikacin / adverse effects* anti-bacterial agents / adverse effects* drug monitoring* amikacin / therapeutic use amikacin / administration & dosage* anti-bacterial agents / blood amikacin / blood investigators=[] affs=[]) pmid:27494904 doi:10.1093/jac/dkw250 abi jenkins alison h thomson collabauthor(name='(bsac working party on therapeutic drug monitoring)' interrupted time series analysis

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