A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

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ID: 274115
2020
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Adult mammalian brains have largely lost neuroregeneration capability except for a few niches. Previous studies have converted glial cells into neurons, but the total number of neurons generated is limited and the therapeutic potential is unclear. Here, we demonstrate that NeuroD1-mediated in situ a …
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Authors Chen YC;Ma NX;Pei ZF;Wu Z;Do-Monte FH;Keefe S;Yellin E;Chen MS;Yin JC;Lee G;Minier-Toribio A;Hu Y;Bai YT;Lee K;Quirk GJ;Chen G;;
Journal molecular therapy : the journal of the american society of gene therapy
Year 2020
DOI DOI not found
URL
https://www.pubmed.gov/31551137/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't male N.I.H. Extramural Disease Models Animal Rats Sprague-Dawley neuroglia / metabolism transgenic genetic therapy / methods* brain ischemia / therapy* neurons / metabolism* action potentials basic helix-loop-helix transcription factors / metabolism pmid:31551137 pmc6952185 doi:10.1016/j.ymthe.2019.09.003 yu-chen chen ning-xin ma gong chen astrocytes / metabolism* basic helix-loop-helix transcription factors / genetics* cellular reprogramming / genetics* dependovirus / genetics nerve degeneration / therapy

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