Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: deficiencies in both IL-12 heterodimer production and IL-12 responsiveness

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ID: 273865
1999
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Abstract
Mice exposed to sublethal endotoxemia develop short-term endotoxin tolerance, a state characterized by decreased monokine production and enhanced protection against endotoxic lethality. We confirmed that TNF-alpha production is markedly impaired in endotoxin-tolerant mice and additionally found 2- t ā€¦
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Authors Balkhy HH;Heinzel FP;;
Journal Journal of immunology (Baltimore, Md. : 1950)
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10092824
Keywords
injections National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. female P.H.S. Cells Cultured Receptors Messenger / biosynthesis interleukin-12 / genetics spleen / metabolism recombinant proteins / pharmacology recombinant proteins / administration & dosage tumor necrosis factor-alpha / pharmacology lymphocyte count inbred c3h tumor necrosis factor-alpha / antagonists & inhibitors immune sera / pharmacology killer cells natural / metabolism tumor necrosis factor-alpha / biosynthesis spleen / cytology dimerization pmid:10092824 h h balkhy f p heinzel drug tolerance endotoxins / administration & dosage* intraperitoneal interferon inducers / administration & dosage* interferon-gamma / antagonists & inhibitors interferon-gamma / biosynthesis* interleukin-10 / immunology interleukin-12 / administration & dosage* interleukin-12 / antagonists & inhibitors* interleukin-12 / biosynthesis interleukin-18 / pharmacology lipopolysaccharides / administration & dosage messenger / antagonists & inhibitors interleukin / genetics interleukin-12

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