Azaspiracid substituent at C1 is relevant to in vitro toxicity

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ID: 273323
2008
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Abstract
The azaspiracids are a group of marine toxins recently described that currently includes 20 analogues. Not much is known about their mechanism of action, although effects on some cellular functions have been found in vitro. We used the reported effects on cell viability, actin cytoskeleton, and casp …
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Authors Vilariño N;Nicolaou KC;Frederick MO;Cagide E;Alfonso C;Alonso E;Vieytes MR;Botana LM;;
Journal Chemical research in toxicology
Year 2008
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/18707138
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. N.I.H. Extramural Cells Cultured Rats dose-response relationship drug kinetics enzyme activation / drug effects cell survival / drug effects molecular conformation structure-activity relationship stereoisomerism pmid:18707138 pmc2559976 doi:10.1021/tx800165c natalia vilariño k c nicolaou luis m botana caspase inhibitors caspases / metabolism cytoskeleton / chemistry cytoskeleton / drug effects furans / chemical synthesis furans / chemistry* furans / toxicity marine toxins / chemical synthesis marine toxins / chemistry* marine toxins / toxicity* pyrans / chemical synthesis pyrans / chemistry* pyrans / toxicity spiro compounds / chemical synthesis spiro compounds / chemistry* spiro compounds / toxicity*

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