The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes

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2011
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Abstract
To identify endoplasmic reticulum (ER) stress-induced microRNAs (miRNA) that govern ER protein influx during the adaptive phase of unfolded protein response, we performed miRNA microarray profiling and analysis in human airway epithelial cells following ER stress induction using proteasome inhibitio ā€¦
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Authors Bartoszewski R;Brewer JW;Rab A;Crossman DK;Bartoszewska S;Kapoor N;Fuller C;Collawn JF;Bebok Z;;
Journal The Journal of biological chemistry
Year 2011
DOI DOI not found
URL
https://www.pubmed.gov/22002058/
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural DNA-Binding Proteins / metabolism* Transcription Factors / metabolism* micrornas / genetics micrornas / metabolism* gene expression profiling hela cells histocompatibility antigens class i / genetics dna-binding proteins / genetics transcription factors / genetics atp binding cassette transporter DNA-Binding Proteins / immunology regulatory factor x transcription factors x-box binding protein 1 unfolded protein response / physiology* transcription factors / immunology pmid:22002058 pmc3308892 doi:10.1074/jbc.m111.304956 rafal bartoszewski joseph w brewer zsuzsa bebok 3' untranslated regions / physiology* subfamily b member 2 atp-binding cassette transporters / biosynthesis* atp-binding cassette transporters / genetics atp-binding cassette transporters / immunology gene expression regulation / physiology* histocompatibility antigens class i / biosynthesis histocompatibility antigens class i / immunology micrornas / immunology

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