Fishing of α-Glucosidase's Ligands from by α-Glucosidase Functionalized Magnetic Nanoparticles.
Clicks: 178
ID: 273235
2021
α-Glucosidase was immobilized on magnetic nanoparticles (MNPs) for selective solid-phase extraction of the enzyme's ligands present in , which is a medicinal plant used for the treatment of various diseases and possesses anti-diabetic activity. One new compound, aloeacone (), together with two known compounds, aloenin aglycone () and aloin A (), were fished out as the enzyme's ligands. The structure of was determined by HR-MS and comprehensive NMR techniques. Compound exhibited a weak inhibitory effect on α-glucosidase, while compounds and were found to possess activation effects on the enzyme for the first time. It is interesting that both an inhibitor and agonists of α-glucosidase were fished out in one experiment.
| Reference Key |
yuan2021fishingmolecules
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yuan, Hao;Wan, Hong;Hu, Yi-Kao;Ayeni, Emmanuel Ayodeji;Chang, Qiang;Ma, Chao;Liao, Xun; |
| Journal | Molecules (Basel, Switzerland) |
| Year | 2021 |
| DOI | 5840 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.