Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection

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2015
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Among patients with HCV genotype 2 or 3 with or without previous treatment, including those with compensated cirrhosis, 12 weeks of treatment with sofosbuvir-velpatasvir resulted in rates of sustained virologic response that were superior to those with standard treatment with sofosbuvir-ribavirin. ( …
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Authors Foster GR;Afdhal N;Roberts SK;Bräu N;Gane EJ;Pianko S;Lawitz E;Thompson A;Shiffman ML;Cooper C;Towner WJ;Conway B;Ruane P;Bourlière M;Asselah T;Berg T;Zeuzem S;Rosenberg W;Agarwal K;Stedman CA;Mo H;Dvory-Sobol H;Han L;Wang J;McNally J;Osinusi A;Brainard DM;McHutchison JG;Mazzotta F;Tran TT;Gordon SC;Patel K;Reau N;Mangia A;Sulkowski M; ; ;;
Journal The New England journal of medicine
Year 2015
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/26575258
Keywords
hepatitis c National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't adult female male aged middle aged young adult 80 and over Clinical Trial Phase III Randomized Controlled Trial Multicenter Study Viral Genotype drug resistance drug combinations antiviral agents / therapeutic use* chronic / complications chronic / virology antiviral agents / adverse effects hepacivirus / genetics* chronic / drug therapy* investigators=[] affs=[]) nezam afdhal graham r foster carbamates / adverse effects carbamates / therapeutic use* heterocyclic compounds 4 or more rings / adverse effects 4 or more rings / therapeutic use* sofosbuvir / adverse effects sofosbuvir / therapeutic use* liver cirrhosis / etiology viral nonstructural proteins / antagonists & inhibitors pmid:26575258 doi:10.1056/nejmoa1512612 collabauthor(name='astral-3 investigators' liver cirrhosis / drug therapy

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