Prostate tumor progression is mediated by a paracrine TGF-β/Wnt3a signaling axis - Oncogene

Clicks: 253
ID: 271799
2008
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
Transforming growth factor (TGF)-β is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-β receptors initiate downstream signaling. The role of stromal TGF-β signaling in prostate cancer progression is unknown. In mice, the conditional stromal knockout of the TGF-β type II receptor expression (Tgfbr2fspKO) resulted in the development of prostatic intraepithelial neoplasia and progression to adenocarcinoma within 7 months. Clinically, we observed a loss of TGF-β receptor type II expression in 69% of human prostate cancer-associated stroma, compared to 15% of stroma associated with benign tissues (n=140, P-value
Reference Key
x2008oncogeneprostate1 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A;Li, X;Placencio, V;Iturregui, J M;Uwamariya, C;Sharif-Afshar, A-R;Koyama, T;Hayward, S W;Bhowmick, N A;
Journal Oncogene
Year 2008
DOI doi:10.1038/onc.2008.293
URL
https://doi.org/10.1038%2Fonc.2008.293
Keywords
cell biology oncology apoptosis internal medicine general medicine/public health human genetics

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.