A new secreted protein that binds to Wnt proteins and inhibits their activities

Clicks: 259
ID: 271301
1999
The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes. Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wn …
Reference Key
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Authors Hsieh JC;Kodjabachian L;Rebbert ML;Rattner A;Smallwood PM;Samos CH;Nusse R;Dawid IB;Nathans J;;
Journal Nature
Year 1999
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10201374
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't amino acid sequence Immunoglobulin G / metabolism Molecular Sequence Data sequence homology amino acid recombinant fusion proteins / genetics carrier proteins / genetics cricetinae signal transduction protein binding recombinant fusion proteins / metabolism carrier proteins / metabolism* adaptor proteins signal transducing cho cells drosophila proteins* xenopus wnt proteins repressor proteins* proto-oncogene proteins / metabolism* zebrafish intercellular signaling peptides and proteins xenopus proteins zebrafish proteins* intracellular signaling peptides and proteins wnt1 protein carrier proteins / isolation & purification pmid:10201374 doi:10.1038/18899 j c hsieh l kodjabachian j nathans extracellular matrix proteins immunoglobulin g / genetics proto-oncogene proteins / antagonists & inhibitors

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