Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices

Clicks: 192
ID: 270915
2009
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Abstract
Here we show that endothelial cells (EC) require matrix type 1-metalloproteinase (MT1-MMP) for the formation of lumens and tube networks in 3-dimensional (3D) collagen matrices. A fundamental consequence of EC lumen formation is the generation of vascular guidance tunnels within collagen matrices th ā€¦
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Authors Stratman AN;Saunders WB;Sacharidou A;Koh W;Fisher KE;Zawieja DC;Davis MJ;Davis GE;;
Journal Blood
Year 2009
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19339693
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural Cells Cultured substrate specificity biocatalysis pmid:19339693 pmc2714200 doi:10.1182/blood-2008-12-196451 amber n stratman w brian saunders george e davis blood vessels / enzymology* collagen / metabolism* endothelial cells / cytology endothelial cells / enzymology* matrix metalloproteinase 14 / genetics matrix metalloproteinase 14 / metabolism* small interfering / genetics

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