Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment

Clicks: 194
ID: 270731
2006
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Abstract
Prenatal testosterone (T) excess during midgestation leads to estrous cycle defects and polycystic ovaries in sheep. We hypothesized that follicular persistence causes polycystic ovaries and that cyclic progesterone (P) treatment would overcome follicular persistence and restore cyclicity. Twice-wee ā€¦
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Authors Manikkam M;Steckler TL;Welch KB;Inskeep EK;Padmanabhan V;;
Journal endocrinology
Year 2006
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16373416
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine research support female N.I.H. Extramural sexual maturation / drug effects ovulation / drug effects progesterone / blood testosterone / toxicity* sheep fetus / drug effects* progesterone / pharmacology* ovarian follicle / physiology mohan manikkam vasantha padmanabhan pmid:16373416 doi:10.1210/en.2005-1338 teresa l steckler estrus / drug effects luteal phase / drug effects ovarian follicle / drug effects* polycystic ovary syndrome / etiology

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