Phosphorylated CREB binds specifically to the nuclear protein CBP

Clicks: 254
ID: 270516
1993
Cyclic AMP-regulated gene expression frequently involves a DNA element known as the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. This modification stimulates interact …
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Authors Chrivia JC;Kwok RP;Lamb N;Hagiwara M;Montminy MR;Goodman RH;;
Journal Nature
Year 1993
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8413673
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Molecular animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't amino acid sequence P.H.S. cell line DNA Genes Nuclear Proteins / metabolism* Transcription Factors / metabolism* Base Sequence Molecular Sequence Data recombinant fusion proteins / genetics cyclic amp-dependent protein kinases / metabolism cloning protein binding phosphorylation reporter binding sites recombinant fusion proteins / metabolism gene expression regulation / physiology creb-binding protein trans-activators* cyclic amp response element-binding protein / genetics cyclic amp response element-binding protein / metabolism* pmid:8413673 doi:10.1038/365855a0 j c chrivia r p kwok r h goodman cyclic amp / physiology thyroid gland / metabolism

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