Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female

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ID: 269950
2005
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Abstract
Exposure of female sheep fetuses to excess testosterone (T) during early to midgestation produces postnatal hypergonadotropism manifest as a selective increase in LH. This hypergonadotropism may result from reduced sensitivity to estradiol (E2) negative feedback and/or increased pituitary sensitivit ā€¦
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hn2005endocrinologyfetal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sarma HN;Manikkam M;Herkimer C;Dell'Orco J;Welch KB;Foster DL;Padmanabhan V;;
Journal endocrinology
Year 2005
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15976056
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine pregnancy research support non-u.s. gov't u.s. gov't female male N.I.H. Extramural P.H.S. luteinizing hormone / metabolism* sexual maturation / drug effects testosterone / pharmacology* feedback sheep follicle stimulating hormone / pharmacology* fetus / drug effects estradiol / administration & dosage estradiol / pharmacology* pmid:15976056 doi:10.1210/en.2005-0322 hirendra n sarma mohan manikkam vasantha padmanabhan drug implants fetus / physiology*

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