A case of the 'dapsone syndrome'
Clicks: 151
ID: 269418
1994
The 'dapsone syndrome' developed in a 44-year-old woman who was treated for pyoderma gangrenosum with 100 mg/day dapsone for about 5 weeks. Symptoms included fever, malaise, jaundice with hepatic dysfunction, lymphadenopathy, mononucleosis and dermatitis. These symptoms disappeared with 30 mg/day of oral prednisolone. A lymphocyte stimulation test with dapsone was positive, as was the delayed-type intradermal skin test with 0.5 and 0.05% dapsone in saline. Immunohistochemical studies of the rash and skin test reaction revealed that the dominant infiltrating T cells in the upper dermis were of the Leu 2a+ cytotoxic/suppressor-type rather than the Leu 3a+ helper/delayed hypersensitivity-type.
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kim1994clinicala
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| Authors | S. Saito,Z. Ikezawa,H. Miyamoto,S. Kim;S. Saito;Z. Ikezawa;H. Miyamoto;S. Kim; |
| Journal | clinical and experimental dermatology |
| Year | 1994 |
| DOI | 10.1111/j.1365-2230.1994.tb01146.x |
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