Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection

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ID: 269180
2006
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Abstract
Influenza is a highly infectious disease characterized by recurrent annual epidemics and unpredictable major worldwide pandemics. Rapid spread of the highly pathogenic avian H5N1 strain and escalating human infections by the virus have set off the alarm for a global pandemic. To provide an urgently ā€¦
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Authors Malakhov MP;Aschenbrenner LM;Smee DF;Wandersee MK;Sidwell RW;Gubareva LV;Mishin VP;Hayden FG;Kim DH;Ing A;Campbell ER;Yu M;Fang F;;
Journal Antimicrobial agents and chemotherapy
Year 2006
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16569867
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support female N.I.H. Extramural cell line Inbred BALB C dogs antiviral agents / pharmacology* influenza virus replication / drug effects human / drug therapy ferrets orthomyxoviridae / drug effects* pmid:16569867 pmc1426979 doi:10.1128/aac.50.4.1470-1479.2006 michael p malakhov laura m aschenbrenner fang fang amphiregulin bacterial adhesion / drug effects catalytic domain egf family of proteins glycoproteins / pharmacology* intercellular signaling peptides and proteins / pharmacology* neuraminidase / chemistry neuraminidase / pharmacology* peptide fragments / pharmacology* recombinant fusion proteins / isolation & purification recombinant fusion proteins / pharmacology*

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