Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence

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ID: 268930
2021
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Abstract
This finding unveils that it is worth taking advantage of tumor lipid addiction, as a tumor vulnerability to design novel treatment strategy to prevent cancer recurrence.
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Authors Luis G;Godfroid A;Nishiumi S;Cimino J;Blacher S;Maquoi E;Wery C;Collignon A;Longuespée R;Montero-Ruiz L;Dassoul I;Maloujahmoum N;Pottier C;Mazzucchelli G;Depauw E;Bellahcène A;Yoshida M;Noel A;Sounni NE;;
Journal Redox biology
Year 2021
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/34030117
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE local tumor microenvironment humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Fatty Acids neoplasm recurrence fatty acid-binding proteins pmid:34030117 pmc8163990 doi:10.1016/j.redox.2021.102006 géraldine luis adrien godfroid nor eddine sounni endothelial cells / metabolism ferroptosis* stearoyl-coa desaturase / metabolism

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