Genetic analysis of chemoresistance in primary murine lymphomas

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2000
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Abstract
Understanding the basis of chemoresistance is a principal goal of molecular oncology. We have exploited a murine lymphoma model and retroviral gene transfer to rapidly generate a series of spontaneous tumors differing only in a gene of interest, and subsequently studied the impact of the test gene o ā€¦
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Authors Schmitt CA;Rosenthal CT;Lowe SW;;
Journal Nature Medicine
Year 2000
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10973324
Keywords
experimental National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Cultured Genes drug resistance adaptation biological transgenic neoplasms tumor cells clone cells gene transfer techniques lymphoma / genetics* pmid:10973324 doi:10.1038/79542 c a schmitt c t rosenthal s w lowe culture techniques / methods multiple / genetics* bcl-2* proto-oncogene proteins c-myc / biosynthesis proto-oncogene proteins c-myc / genetics retroviridae / genetics

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