The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism

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ID: 268390
1998
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Abstract
We have previously shown that intracerebroventricular BIBP 3226 inhibits NPY induced feeding in rats. However, this was associated with abnormal behaviour, likely to be due to interaction with Y1 receptors involved in mechanisms other than the control of food intake. In order to minimise such intera ā€¦
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Authors Morgan DG;Small CJ;Abusnana S;Turton M;Gunn I;Heath M;Rossi M;Goldstone AP;O'Shea D;Meeran K;Ghatei M;Smith DM;Bloom S;;
Journal Regulatory peptides
Year 1998
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9802432
Keywords
injections National Center for Biotechnology Information NCBI NLM MEDLINE animals pubmed abstract nih national institutes of health national library of medicine male Rats Receptors dose-response relationship drug wistar arginine / pharmacology arginine / analogs & derivatives* eating / physiology stereoisomerism pmid:9802432 doi:10.1016/s0167-0115(98)00091-3 d g morgan c j small s bloom arginine / administration & dosage arginine / chemistry eating / drug effects* neuropeptide y / administration & dosage neuropeptide y / pharmacology* neuropeptide y / physiology paraventricular hypothalamic nucleus / drug effects paraventricular hypothalamic nucleus / physiology neuropeptide y / antagonists & inhibitors*

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