Effect of okadaic acid on integrins and structural proteins in BE(2)-M17 cells - Archives of Toxicology

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2005
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Abstract
Okadaic acid (OA), an algal toxin, is known to induce Diarrhetic Shellfish Poisoning and apoptosis in a variety of cell lines. One of the main targets of OA is the actin cytoskeleton which can be modulated by integrins and other structural proteins. In this paper we studied the role of these proteins and skeletal structures on OA-induced apoptosis in neuroblastoma cells. Results show that Ī²1 integrin and vinculin are down-regulated when cells were exposed to OA. We observed an interaction between talin and Ī²1 integrin that is impaired in OA treated cells.
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Authors Francisco Santaclara;Jorge Lago;Juan M. Vieites;Ana G. Cabado;Francisco Santaclara;Jorge Lago;Juan M. Vieites;Ana G. Cabado;
Journal archives of toxicology
Year 2005
DOI doi:10.1007/s00204-005-0679-z
URL
https://doi.org/10.1007/s00204-005-0679-z
Keywords
environmental health biomedicine general pharmacology/toxicology occupational medicine/industrial medicine

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