Function and biological roles of the Dickkopf family of Wnt modulators - Oncogene

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ID: 267953
2006
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Abstract
Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted proteins that typically antagonize Wnt/β-catenin signaling, by inhibiting the Wnt coreceptors Lrp5 and 6. Additionally, Dkks are high affinity ligands for the transmembrane proteins Kremen1 and 2, which also modulate Wnt signaling. Dkks play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero–posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
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niehrs2006oncogenefunction Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors C Niehrs;C Niehrs;
Journal Oncogene
Year 2006
DOI doi:10.1038/sj.onc.1210054
URL
https://doi.org/10.1038%2Fsj.onc.1210054
Keywords
cell biology oncology apoptosis internal medicine general medicine/public health human genetics

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