Incidence of childhood pneumonia and serotype and sequence-type distribution inStreptococcus pneumoniaeisolates in Japan

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ID: 267495
2011
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Abstract
SUMMARYThe 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We investigated serotype and multilocus sequence typing (MLST) forStreptococcus pneumoniaeisolates in CAP cases. The annual incidence of hospitalized CAP in children aged S. pneumoniaewas dominant in 14·7% and 0·8% of sputum and blood samples, respectively. The most common serotypes were 6B, 23F and 19F. The coverage rates of PCV7 were 66·7% and 80% in sputum samples and blood samples, respectively. MLST analysis revealed 37 sequence types. Furthermore, 54·1% of the sputum isolates and 40% of the blood isolate were related to international multidrug-resistant clones.
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Authors J. Tanaka,N. Ishiwada,A. Wada,B. Chang,H. Hishiki,T. Kurosaki,Y. Kohno;J. Tanaka;N. Ishiwada;A. Wada;B. Chang;H. Hishiki;T. Kurosaki;Y. Kohno;
Journal epidemiology and infection
Year 2011
DOI 10.1017/s0950268811001592
URL
https://sciprofiles.com/publication/view/13509b7f21fd59e46227660a125b7329
Keywords
antibiotic resistance community-acquired pneumonia incidence immunization (vaccination) streptococcus pneumoniae (pneumococcus)

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